中 (zhōng): Center, middle. The character is a pictogram of a box with a line passing through its center.
央 (yāng): Center, central. Often paired with 中 to form `中央 (zhōngyāng)`, emphasizing the absolute center or central authority.
商 (shāng): Commerce, business, trade.
务 (wù): Affairs, business matters. When combined, `商务 (shāngwù)` means “business” or “commercial affairs.”
区 (qū): District, area, region.
The characters combine literally and logically: `中央 (central)` + `商务 (business)` + `区 (district)` = Central Business District. It's a modern, direct-translation term created to describe a modern urban feature.